Our understanding of the causes of atherosclerosis and heart disease is astonishingly recent. Somehow we assume that we always knew that high cholesterol caused heart disease. Not so. Just consider that President Franklin Roosevelt died of untreated hypertension in the range of 240/140 largely because we did not yet know that it was a treatable disease.
We owe much of our understanding of the causes and risk factors for heart disease to the Framingham Heart Study. Look at some of the important firsts they made:
1948 Framingham study starts
1957 High blood pressure and cholesterol shown to increase risk of heart disease
1961 The term "risk factor" is introduced
1962 Cigarette smoking found to cause heart disease
1974 Diabetes and its association with heart disease described
1977 Total, LDL, and HDL cholesterols linked to heart disease (although the "normal" levels were shockingly high by today's standard definitions
1988 the benefit of a high level of HDL is described
1993 Mild isolated systolic hypertension shown to increase risk of heart disease
1998 New models to predict risk of heart disease developed.
Sixty years of heart leadership. We are all healthier because of the great work of Framingham. Thank you.